First Generation Hybrid Columns
Based upon first generation hybrid(inorganic/organic) particles, the XTerra® family of HPLC columns enables chromatographers to perform high pH drug discovery, method development and purification separations.
XTerra® Columns combine the best properties of silica and polymeric bonded phases with patented Hybrid Particle Technology that replaces one out of every three silanols with a methyl group during particle synthesis. This hydrophobicity is distributed through the entire structure of the particle backbone, resulting in a rugged hybrid particle that can be operated at high speeds, high temperatures and at high pH. The presence of 33% fewer residual silanols(after endcapping and bonding) also means that XTerra columns give exceptionally sharp, high-efficiency peaks for basic compounds
XTerra Columns wide pH range enables method development scientists to operate at the mobile phase pH necessary for optimal selectivity. These HPLC columns make it possible to develop robust separations in less time.
VanGuard Column Protection
The often complex sample matrices encountered in pharmaceutical, natural product, environmental, and industrial chemical analysis prematurely shorten analytical column lifetime and degrade chromatographic performance. Waters VanGuard Cartridge Columns help improve analytical column performance by removing particulate and chemical contamination that may be present in the mobile-phase stream—without compromising chromatographic performance.
Isolation and Purification
Combining the patented Optimum Bed Density(OBD) design with the unique chromatographic properties of Hybrid Particle Technology enables XTerra® Prep OBD Chromatography Columns to deliver analytical performance in preparative dimensions with maximum column stability. XTerra Prep OBD™ Columns offer unprecedented flexibility through basic, acidic and polar analytes and the wide operating range of mobile phases necessary for successful, predictable preparative scale-up.