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BioPro Series
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Description
Parameters
BioPro Series
BioPro and BioPro SmartSep, ion exchange media with high dynamic binding capacities and high recoveries, are suitable for downstream chromatographic purification processes in biopharmaceutical manufacturing. BioPro and BioPro SmartSep are suitable for initial purification(capture) and for intermediate to final purification(polishing), respectively.
YMC-BioPro, ion exchange columns with high resolution, are suitable for uniformity tests, such as isoform analysis in quality control and characterization of biopharmaceuticals.
Media
BioPro Ion Exchange Media | BioPro SmartSep | |||||
|---|---|---|---|---|---|---|
BioPro Q |
BioPro S |
BioPro DA |
BioPro CM |
BioPro SmartSep Q |
BioPro SmartSep S |
|
Matrix |
Hydrophilic porous polymer |
|||||
Particle size(μm) |
75 |
60 |
10, 20, 30 |
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Ion exchanger |
-R-N+(CH3)3 |
-R-SO3- |
-R-N(CH3)2 |
-R-COOH |
-R-N+(CH3)3 |
-R-SO3- |
Feature |
Suitable for capture and intermediate purification step High binding capacity |
Suitable for intermediate purification step and polishing step High-throughput purification by utilizing mechanical strength polymer beads |
||||
BioPro Ion Exchange Screening Kit
Available in four chemistries: Strong ion exchangers and weak ion exchangers
For media screening, develop of purification method and loadability study
Column
YMC-BioPro(packed column) | ||||
|---|---|---|---|---|
YMC-BioPro QA-F |
YMC-BioPro SP-F |
YMC-BioPro QA |
YMC-BioPro SP |
|
Matrix |
Hydrophilic non-porous polymer |
Hydrophilic porous polymer |
||
Particle size(μm) |
3, 5 |
5 |
||
Ion exchanger |
-CH2N+(CH3)3 |
-CH2CH2CH2SO3- |
-CH2N+(CH3)3 |
-CH2CH2CH2SO3- |
Feature |
For increasing resolution and throughput High efficiency with low operating pressure Suitable for characterization of biopharmaceuticals and quality control |
Suitable for laboratory-scale purification High binding capacity and high recovery of biomolecules |
||
Products subjected to purification process of biopharmaceuticals
Process |
Required media performance |
BioPro products | ||
|---|---|---|---|---|
Capture |
High binding capacity in high flow rate Excellent characteristic of pressure and flow rate realizing high flow rate |
BioPro(75, 60 μm) |
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Intermediate |
High resolution to remove most of impurity High binding capacity Easy to scale up Excellent mechanical strength and pressure resistance |
BioPro SmartSep |
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Polishing |
Quite high performance to separate impurities whose retention time close to each other Low nonspecific binding capacity |
|||
Analytical |
High resolution and excellent lot-to-lot reproducibility |
YMC-BioPro(packed column) |
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